Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility.

@article{Yazdani1999FunctionalSO,
  title={Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility.},
  author={Arrash T. Yazdani and Toku Takahashi and Didier Bagnol and Stanley J. Watson and Chung Owyang},
  journal={Gastroenterology},
  year={1999},
  volume={116 1},
  pages={108-17}
}
BACKGROUND & AIMS Orphanin FQ (OFQ) is a recently discovered neuropeptide that structurally resembles an opioid peptide. However, the functional role of OFQ in rat gastrointestinal tract remains unknown. METHODS We investigated the effects of OFQ on contractions of muscle strips obtained from different regions of the gastrointestinal tract. Immunohistochemical studies were performed on rat colonic tissue using OFQ antibody. RESULTS OFQ (10(-9) to 10(-7) mol/L) caused significant… CONTINUE READING

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