Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3).

@article{Lakhman2005FunctionalSO,
  title={Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3).},
  author={Sukhwinder S. Lakhman and Debashis Ghosh and Javier G Blanco},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 2},
  pages={254-7}
}
Human carbonyl reductase (CBR) activity accounts for a significant fraction of the metabolism of endogenous and xenobiotic carbonyl compounds. It is possible that genetic polymorphisms in CBR1 and CBR3 are key for the wide interindividual variability in the disposition of CBR drug substrates. We pinpointed a single nucleotide polymorphism in CBR3 (CBR3 V244M) that encodes for a V244 to M244 change. Blacks showed a higher frequency of the M244 allele (q = 0.51, n = 49) than did whites (q = 0.31… CONTINUE READING
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