Functional significance and mechanism of eIF5-promoted GTP hydrolysis in eukaryotic translation initiation.

@article{Das2001FunctionalSA,
  title={Functional significance and mechanism of eIF5-promoted GTP hydrolysis in eukaryotic translation initiation.},
  author={Supratik Das and Umadas Maitra},
  journal={Progress in nucleic acid research and molecular biology},
  year={2001},
  volume={70},
  pages={207-31}
}
Eukaryotic translation initiation factor 5 (eIF5), a monomeric protein of about 49 kDa in mammals and 46 kDa in the yeast Saccharomyces cerevisiae, in conjunction with GTP and other initiation factors plays an essential role in initiation of protein synthesis in eukaryotic cells. Following formation of the 40S initiation complex (40S . eIF3 . mRNA . Met-tRNAf . eIF2 . GTP) at the AUG codon of an mRNA, eIF5 interacts with the 40S initiation complex to promote the hydrolysis of bound GTP… CONTINUE READING
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