Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.

@article{Mottola2002FunctionalSO,
  title={Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.},
  author={D. Mottola and J. Kilts and M. Lewis and H. Connery and Q. D. Walker and Sara R. Jones and R. Booth and D. K. Hyslop and M. Piercey and R. Wightman and C. Lawler and D. E. Nichols and R. Mailman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 3},
  pages={
          1166-78
        }
}
Dihydrexidine (DHX), the first high-affinity D(1) dopamine receptor full agonist, is only 10-fold selective for D(1) versus D(2) receptors, having D(2) affinity similar to the prototypical agonist quinpirole. The D(2) functional properties of DHX and its more D(2) selective analog N-n-propyl-dihydrexidine (PrDHX) were explored in rat brain and pituitary. DHX and PrDHX had binding characteristics to D(2) receptors in rat striatum typical of D(2) agonists, binding to both high- and low-affinity… Expand
Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.
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Discovery of D 1 Dopamine Receptor Positive Allosteric Modulators : Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity s
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitiveExpand
Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitiveExpand
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