Functional selectivity in adrenergic and angiotensin signaling systems.

  title={Functional selectivity in adrenergic and angiotensin signaling systems.},
  author={Chetan B. Patel and Nabila Noor and Howard A Rockman},
  journal={Molecular pharmacology},
  volume={78 6},
β-Adrenergic and angiotensin II type 1A receptors are therapeutic targets for the treatment of a number of common human diseases. Pharmacological agents designed as antagonists for these receptors have positively affected the morbidity and mortality of patients with hypertension, heart failure, and renal disease. Antagonism of these receptors, however, may only partially explain the therapeutic benefits of β-blockers and angiotensin receptor blockers given the emerging concept of functional… CONTINUE READING
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