Functional screening identifies miRNAs inducing cardiac regeneration

@article{Eulalio2012FunctionalSI,
  title={Functional screening identifies miRNAs inducing cardiac regeneration},
  author={Ana Eulalio and Miguel Mano and Matteo Dal Ferro and Lorena Zentilin and Gianfranco Sinagra and Serena Zacchigna and Mauro Giacca},
  journal={Nature},
  year={2012},
  volume={492},
  pages={376-381}
}
In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of the minimal renewal of cardiomyocytes during adult life, repair of cardiac damage through myocardial regeneration is very limited. Here we show that the exogenous administration of… CONTINUE READING
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