Functional rules for lac repressor-operator associations and implications for protein-DNA interactions.

@article{Milk2010FunctionalRF,
  title={Functional rules for lac repressor-operator associations and implications for protein-DNA interactions.},
  author={Leslie Milk and Robert D. Daber and Mitchell Lewis},
  journal={Protein science : a publication of the Protein Society},
  year={2010},
  volume={19 6},
  pages={1162-72}
}
The Lac repressor has been used as a tool to understand protein-DNA recognition for many years. Recent experiments have demonstrated the ability of the Lac repressor to control gene expression in various eukaryotic systems, making the quest for an arsenal of protein-DNA binding partners desirable for potential therapeutic applications. Here, we present the results of the most exhaustive screen of Lac repressor-DNA binding partners to date, resulting in the elucidation of functional rules for… CONTINUE READING