Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.

@article{Chen2000FunctionalRO,
  title={Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.},
  author={Jia Lin Chen and John S. Mitcheson and M Lin and Michael C Sanguinetti},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 46},
  pages={36465-71}
}
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to pacemaking activity in specialized neurons and cardiac myocytes. HCN channels have a structure similar to voltage-gated K(+) channels but have a much larger putative S4 transmembrane domain and open in response to membrane hyperpolarization instead of depolarization. As an initial attempt to define the structural basis of HCN channel gating, we have characterized the functional roles of the charged residues in the… CONTINUE READING
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