Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle.

@article{Yoshiyama2015FunctionalRO,
  title={Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle.},
  author={Mitsuharu Yoshiyama and Tsutomu Mochizuki and Hiroshi Nakagomi and Tatsuya Miyamoto and Satoru Kira and Ryoji Mizumachi and Takaaki Sokabe and Yasunori Takayama and Makoto Tominaga and Masayuki Takeda},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={308 10},
  pages={
          F1128-34
        }
}
The present study used a dual analysis of voiding behavior and reflex micturition to examine lower urinary tract function in transient receptor potential vanilloid (TRPV)1 knockout (KO) mice and TRPV4 KO mice. In metabolic cage experiments conducted under conscious conditions (i.e., voluntary voiding behavior), TRPV4 KO mice showed a markedly higher voiding frequency (VF; 19.3 ± 1.2 times/day) and a smaller urine volume/voiding (UVV; 114 ± 9 μl) compared with wild-type (WT) littermates (VF: 5.2… 

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