Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.

@article{Kinzel2014FunctionalRO,
  title={Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.},
  author={Bernd Kinzel and Monika Pikiolek and Vanessa Orsini and Jo{\"e}lle Sprunger and Andrea Isken and Svenja Zietzling and Magali Desplanches and Val{\'e}rie Dubost and Daniel Breustedt and Reginald Valdez and Dong Liu and Diethilde Theil and Matthias Otto M{\"u}ller and Bill Dietrich and Tewis Bouwmeester and Heinz Ruffner and Jan S. Tchorz},
  journal={Developmental biology},
  year={2014},
  volume={390 2},
  pages={181-90}
}
Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs. However, whether Lgr4 and Lgr5 are important for embryonic development remains unclear. To study their functions during intestinal crypt, skin and kidney development we now generated mice lacking either Lgr4 (Lgr4KO), Lgr5 (Lgr5KO) or both receptors (Lgr4/5dKO). E16.5 Lgr4KO mice displayed complete loss of Lgr5+/Olfm4+intestinal stem cells, compromised Wnt signaling and impaired proliferation and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…