Functional roles of CCL5/RANTES in liver disease

  title={Functional roles of CCL5/RANTES in liver disease},
  author={Lili Chen and Qian-fei Zhang and Chang Yu and Fang Wang and Xiaoni Kong},
  journal={Liver Research},

Regulation and functional roles of chemokines in liver diseases

The regulation of chemokines in the liver, their roles in liver diseases and the potential therapeutic targets are described.

Prognostic, clinical, and therapeutic importance of RANTES‐CCR5 axis in hepatitis A infection: A multiapproach study

The study suggests the importance of RANTES‐CCR5 signaling and linked‐immunomodulation in HAV disease pathogenesis, as well as highlights the utility of CCR5 antagonists as a risk‐reduction strategy in FHF patients.

The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma

Insight is provided on cytokines with clinical relevance for HCC differentiating those implicated in tumor formation, early detection, advanced disease, and response to therapy.

Chemokines and chemokine receptors during COVID-19 infection

Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19

A novel approach to resolving unchecked inflammation, restoring immunologic deficiencies, and reducing SARS-CoV-2 plasma viral load via disruption of the CCL5-CCR5 axis is demonstrated and support randomized clinical trials to assess clinical efficacy of leronlimab-mediated inhibition of CCR5 for COVID-19 is supported.

Long non-coding RNAs in metabolic disorders: pathogenetic relevance and potential biomarkers and therapeutic targets

This narrative review described the molecular mechanisms of lncRNAs in the development of metabolic diseases including insulin resistance, diabetes, obesity, non-alcoholic fatty liver disease, cirrhosis, and coronary artery diseases.

A low direct electrical signal attenuates oxidative stress and inflammation in septic rats

Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.



Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice.

The results define a successful therapeutic approach to reduce experimental liver fibrosis by antagonizing Ccl5 receptors and show that treatment with the CCL5 receptor antagonist Met-CCL5 inhibited cultured stellate cell migration, proliferation, and chemokine and collagen secretion.

Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis.

The present review aims at summarizing the contribution of immune cell infiltration as well as related chemokine systems to experimental liver fibrosis and will discuss possible therapeutic applications in humans, with a special emphasis on the monocyte/macrophage lineage and their related Chemokine pathways.

CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization

The data demonstrate CCL5 induction during DILI, identify C CL5 as a novel innate immunity regulator in macrophage polarization, and suggest that CCL 5 blockage is a promising therapeutic strategy for the treatment of DILi.

Chemokine-directed immune cell infiltration in acute and chronic liver disease

Dissecting the exact functional contribution of immune cell subsets, chemokines and chemokine-receptor pathways in liver injury will hopefully identify novel targets for the treatment of acute liver failure, liver fibrosis or cirrhosis.

Early up‐regulation of chemokine expression in fulminant hepatic failure

Serum levels and intrahepatic expression of all chemokines studied in FHF exceeded the levels in chronic liver diseases and normal controls, and data indicate that an abundant intra hepatic release of CC‐chemokines is an early and pivotal step in the pathogenesis of FHF.

CCR5 deficiency exacerbates T‐cell–mediated hepatitis in mice

CCR5 deficiency exacerbates T‐cell–mediated hepatitis, and leads to increased levels of C CR5 ligands and a more pronounced liver mononuclear infiltrate, suggesting that CCR5 expression can modulate severity of immunomediated liver injury.

Interference with Oligomerization and Glycosaminoglycan Binding of the Chemokine CCL5 Improves Experimental Liver Injury

Evidence is provided that inhibition of oligomerization and glycosaminoglycan binding of the chemokines CCL5 is a new therapeutic strategy for the treatment of acute and chronic liver injuries and represents an alternative to chemokine receptor antagonism.

C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury

A sequence of early events elicited by CCL5 chemoattracting macrophage that result in inflammatory aggravation of hepatic IRI are demonstrated.