Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.

@article{Blobe2001FunctionalRF,
  title={Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.},
  author={Gerard C. Blobe and William P. Schiemann and M C P{\'e}pin and Myriam Beauchemin and Aristidis Moustakas and Harvey F. Lodish and Maureen D. O'Connor-McCourt},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 27},
  pages={24627-37}
}
Transforming growth factor beta (TGF-beta) signals through three high affinity cell surface receptors, TGF-beta type I, type II, and type III receptors. The type III receptor, also known as betaglycan, binds to the type II receptor and is thought to act solely by "presenting" the TGF-beta ligand to the type II receptor. The short cytoplasmic domain of the type III receptor is thought to have no role in TGF-beta signaling because deletion of this domain has no effect on association with the type… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…