Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels.

@article{Yang1999FunctionalRF,
  title={Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels.},
  author={Suya Yang and J. Graham and Jonathan Kahn and Eric A. Schwartz and Mary E. Gerritsen},
  journal={The American journal of pathology},
  year={1999},
  volume={155 3},
  pages={887-95}
}
Various in vitro models have been described that emulate one or more of the processes involved in angiogenesis in vivo. In the present study endothelial cells were cultured in three-dimensional type I collagen lattices in the presence of a mixture of basic fibroblast growth factor, vascular endothelial cell growth factor, and phorbol myristate acetate. Under these conditions, the endothelial cells rapidly assemble into an interconnected network of tube-like structures with a high frequency of… CONTINUE READING