Functional role of transient conformations: Rediscovering "chronosteric effects" thirty years later.

@article{Ascenzi2013FunctionalRO,
  title={Functional role of transient conformations: Rediscovering "chronosteric effects" thirty years later.},
  author={Paolo Ascenzi and Stefano Gianni},
  journal={IUBMB life},
  year={2013},
  volume={65 10},
  pages={
          836-44
        }
}
Proteins are dynamic entities that exert, in some cases, their functions via complex pathways, involving active transient species. This phenomenon was highlighted for the first time in 1983 by Antonini et al. (J. Biol. Chem. 258, 4676-4678), who demonstrated that at least one intermediate occurring in the formation of the bovine β-trypsin-Kunitz inhibitor complex displayed catalytic properties different from those of the active enzyme and of the inactive enzyme-inhibitor adduct. Since it was… CONTINUE READING

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