Functional role of the extended loop 2 in the myosin 9b head for binding F-actin.

@article{Struchholz2009FunctionalRO,
  title={Functional role of the extended loop 2 in the myosin 9b head for binding F-actin.},
  author={Sandra Struchholz and Kerstin Elfrink and Uwe Pieper and Georg Kalhammer and Ulrike Honnert and Anika Gr{\"u}tzner and Wolfgang A Linke and Wanqin Liao and Martin B{\"a}hler},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 6},
  pages={3663-71}
}
The mammalian class IX myosin Myo9b can move considerable distances along actin filaments before it dissociates. This is remarkable, because it is single headed and because the rate-limiting step in its ATPase cycle is ATP hydrolysis. Thus, it spends most of its cycling time in the ATP-bound state that has a weak affinity for F-actin in other myosins. It… CONTINUE READING