Functional role of the cytoplasmic domain of the integrin alpha 5 subunit

@article{Bauer1993FunctionalRO,
  title={Functional role of the cytoplasmic domain of the integrin alpha 5 subunit},
  author={Jeffrey S. Bauer and Judy Varner and C. Schreiner and Lori Kornberg and Robert Nicholas and Rudolph L Juliano},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={122},
  pages={209 - 221}
}
The purpose of this study was to explore the functional role of the cytoplasmic domain of the alpha subunit of the alpha 5/beta 1 integrin, a fibronectin receptor. Mutant CHO cells that express very low levels of endogenous hamster alpha 5 subunit (CHO clone B2) were transfected with an expression vector containing full-length or truncated human alpha 5 cDNAs to form chimeric human alpha 5/hamster beta 1 integrins. Three transfectants were examined: B2a27 expresses a full-length human alpha 5… CONTINUE READING

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