Functional role of the cytoplasmic domain of the integrin alpha 5 subunit

  title={Functional role of the cytoplasmic domain of the integrin alpha 5 subunit},
  author={Jeffrey S. Bauer and Judy Varner and C. Schreiner and Lori Kornberg and Robert Nicholas and Rudolph L Juliano},
  journal={The Journal of Cell Biology},
  pages={209 - 221}
The purpose of this study was to explore the functional role of the cytoplasmic domain of the alpha subunit of the alpha 5/beta 1 integrin, a fibronectin receptor. Mutant CHO cells that express very low levels of endogenous hamster alpha 5 subunit (CHO clone B2) were transfected with an expression vector containing full-length or truncated human alpha 5 cDNAs to form chimeric human alpha 5/hamster beta 1 integrins. Three transfectants were examined: B2a27 expresses a full-length human alpha 5… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 61 references

Regulation of adhesion to I-CAM by the cytoplasmic domain of LFA-1 integrin b subunit

  • M. L. Hibbs, H. Xn, S. A. Stacker, T. A. Springer.
  • Science (Wash. DC). 251:1611-1613.
  • 1991
Highly Influential
6 Excerpts

An interaction between a-actinin and the betal integrin subonit in vitro

  • C. A. Otey, F. M. Palvalko, K. Burridge.
  • J. Cell Biol. 111:721-729.
  • 1990
Highly Influential
4 Excerpts

Expression and function of chicken integrin betal subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells

  • Y. Hayashi, B. Halmovich, A. Reska, D. Boettiger, A. Horwitz.
  • J. Cell BioL 110:175-184.
  • 1990
Highly Influential
3 Excerpts

Fluorescence staining of the ectin eytoskeleton in living cells with 7-nitro-benz-2oxal,3 diazole-phallieidin

  • L. S. Barak, R. R. Yokum, E. A. Nothnagel, andW.W. Webb
  • Proc. Natl. Aead. Sci. USA
  • 1980
Highly Influential
3 Excerpts

Focal adhesion protein tyrosine kinase phosphorylated in response to cell spreading on fibronectin

  • S. K. Hanks, M. B. Calab, M. C. Harper, S. K. Patel.
  • Proc. Natl. Acad. Sci. USA. 89:8487-8491.
  • 1992
1 Excerpt

pp 125 FAK , a structurally unique protein tyrosine kinase associated with focal adhesions

  • J. Solowska, J.-L. Gnan, E. E. Marcantonio, J. E. Trevithick, C. A. Buck, R. O. Hynes
  • Proc . Natl . Acad . Sci . USA .
  • 1992

Similar Papers

Loading similar papers…