Functional role of polar amino acid residues in Na+/H+ exchangers.

  title={Functional role of polar amino acid residues in Na+/H+ exchangers.},
  author={Christine A. Wiebe and E R Dibattista and Larry Fliegel},
  journal={The Biochemical journal},
  volume={357 Pt 1},
Na(+)/H(+) exchangers are a family of ubiquitous membrane proteins. In higher eukaryotes they regulate cytosolic pH by removing an intracellular H(+) in exchange for an extracellular Na(+). In yeast and Escherichia coli, Na(+)/H(+) exchangers function in the opposite direction to remove intracellular Na(+) in exchange for extracellular H(+). Na(+)/H(+) exchangers display an internal pH-sensitivity that varies with the different antiporter types. Only recently have investigations examined the… CONTINUE READING
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