Functional role of p38 mitogen activated protein kinase in platelet activation induced by a thromboxane A2 analogue and by 8-iso-prostaglandin F2alpha.

@article{Minuz2002FunctionalRO,
  title={Functional role of p38 mitogen activated protein kinase in platelet activation induced by a thromboxane A2 analogue and by 8-iso-prostaglandin F2alpha.},
  author={Pietro Minuz and Stefania Gaino and Valeria Zuliani and Rosa Maria Tommasoli and Donatella Benati and Riccardo Ortolani and Carlo Zancanaro and Giorgio Berton and Clara Lechi Santonastaso},
  journal={Thrombosis and haemostasis},
  year={2002},
  volume={87 5},
  pages={888-98}
}
We investigated similarities in the signaling pathways elicited by the F2 isoprostane 8-iso-PGF2alpha and by low doses of U46619 to induce platelet activation. Both 0.01-0.1 micromol/L U46619 and 0.01-1 micromol/L 8-iso-PGF2alpha triggered shape change and filopodia extension, as well as adhesion to immobilized fibrinogen of washed platelets. At these doses the two platelet agonists failed to trigger secretion and aggregation, which were however induced by higher doses of U46619 (0.1-1 micromol… CONTINUE READING