Functional role of lipoprotein receptors in Alzheimer's disease.

  title={Functional role of lipoprotein receptors in Alzheimer's disease.},
  author={Sebastian Jaeger and Claus U. Pietrzik},
  journal={Current Alzheimer research},
  volume={5 1},
The LDL receptor gene family constitutes a class of structurally closely related cell surface receptors fulfilling diverse functions in different organs, tissues, and cell types. The LDL receptor is the prototype of this family, which also includes the VLDLR, ApoER2/LRP8, LRP1 and LRP1B, as well as Megalin/GP330, SorLA/LR11, LRP5, LRP6 and MEGF7. Recently several lines of evidence have positioned the LDL receptor gene family as one of the key players in Alzheimer's disease (AD) research… CONTINUE READING


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