Functional role of intravascular coronary endothelial adenosine receptors.

@article{Balcells1992FunctionalRO,
  title={Functional role of intravascular coronary endothelial adenosine receptors.},
  author={Eduardo Balcells and Jorge Su{\'a}rez and Rafael Rubio},
  journal={European journal of pharmacology},
  year={1992},
  volume={210 1},
  pages={
          1-9
        }
}
The endothelium is relatively 'impermeable' to adenosine. In addition, infusion of adenosine deaminase and transient infusion of large size adenosine agonists (molecular weight 100 kD) which are confined to the intravascular space depress effects of endogenous adenosine and retain physiologic activity respectively. Accordingly, the concept that intravascular adenosine may exert some of its action on the capillary lumen was tested by coupling the agonists: N6-([aminoethylamino]carbonyl… Expand
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Results show that both adenosine and theophylline exert their coronary effects at the surface of the smooth muscle cell, but evidence does not establish that they are competing for a common receptor. Expand
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The modulation of insulin action by adenosine has been studied in lipid and glucose metabolism of isolated rat fat cells. When 20000 cells per ml were incubated, insulin failed to antagonize theExpand
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Adenosine's effects on the human HPS are primarily antiadrenergic and are thus consistent with the concept of accentuated antagonism, and may serve as a counterregulatory metabolic response that improves the O2 supply-demand ratio perturbed by enhanced sympathetic tone. Expand
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Adenosine is the primary mediator of Hypoxia-induced atrioventricular conduction delay, and the adenosine receptor that mediates the negative dromotropic effect of hypoxia is similar to that of exogenous adenoine. Expand
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Colocalization experiments carried out with biotinylated primary antibodies indicate that some vessels are positive for both adenosine deaminase and complexing protein, the first experimental evidence of possible in situ association of adenosines deaminasing protein. Expand
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It is concluded that endogenous adenosine inhibits [3H]inositol release, possibly by modulating several of the steps of the inositol phospholipid pathway. Expand
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Ribonucleic acid, adenylic acid, and adenosine (1 mg per ml), when incubated with adipose tissue, increase the utilization of exogenous glucose and increases lipogenesis, and stimulates glyceride-glycerol synthesis. Expand
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