Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma.

  title={Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma.},
  author={Juergen Bukur and Vera Rebmann and Hans Grosse-Wilde and Hans Joachim Luboldt and Herbert Ruebben and Ingo Drexler and Gerd Sutter and Christoph Huber and Barbara Seliger},
  journal={Cancer research},
  volume={63 14},
The nonclassical HLA-G molecule exhibits a limited tissue distribution and exerts multiple immune regulatory functions. Recent studies indicate that HLA-G expression plays a key role in the induction of immune tolerance and may represent a novel immune escape mechanism of tumor cells. Despite a high frequency of tumor-infiltrating T lymphocytes in renal cell carcinoma (RCC) lesions, outgrowth of tumor cells occurs that might be attributable to abrogation-efficient antitumor responses. To… CONTINUE READING


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Aberrant human leucocyte antigen-G expression and its clinical relevance in hepatocellular carcinoma

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