Functional role of estrogen in pituitary tumor pathogenesis.

  title={Functional role of estrogen in pituitary tumor pathogenesis.},
  author={Anthony Patrick Heaney and Manory Fernando and Shlomo Melmed},
  journal={The Journal of clinical investigation},
  volume={109 2},
Pituitary hyperplasia and lactotroph replication are induced by estrogen. The product of the pituitary tumor transforming gene (PTTG) exhibits in vitro and in vivo transforming activity and induces basic bFGF secretion, thereby modulating pituitary angiogenesis and tumor formation. We demonstrated previously that pituitary pttg is induced by estrogen and bFGF, the latter being expressed in a concordant fashion with pttg in experimental and human pituitary adenomas. We now elucidate the role of… CONTINUE READING
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