Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster

  title={Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster},
  author={Artem Bonchuk and Oksana Maksimenko and Olga Kyrchanova and Tatyana Ivlieva and Vladic Mogila and Girish Deshpande and Daniel Wolle and Paul Schedl and Pavel Georgiev},
  booktitle={BMC Biology},
Insulators play a central role in gene regulation, chromosomal architecture and genome function in higher eukaryotes. To learn more about how insulators carry out their diverse functions, we have begun an analysis of the Drosophila CTCF (dCTCF). CTCF is one of the few insulator proteins known to be conserved from flies to man. In the studies reported here we have focused on the identification and characterization of two dCTCF protein interaction modules. The first mediates dCTCF multimerization… CONTINUE READING
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