Functional role of centrosomes in spindle assembly and organization.

  title={Functional role of centrosomes in spindle assembly and organization.},
  author={Hanne Varmark},
  journal={Journal of cellular biochemistry},
  volume={91 5},
The centrosome is the main MT organizing center in animal cells, and has traditionally been regarded as essential for organization of the bipolar spindle that facilitates chromosome segregation during mitosis. Centrosomes are associated with the poles of the mitotic spindle, and several cell types require these organelles for spindle formation. However, most plant cells and some female meiotic systems get along without this organelle, and centrosome-independent spindle assembly has now been… CONTINUE READING