Functional role of Rho-kinase in ameloblast differentiation.

  title={Functional role of Rho-kinase in ameloblast differentiation.},
  author={Keishi Otsu and Ryota Kishigami and Naoki Fujiwara and Kiyoto Ishizeki and Hidemitsu Harada},
  journal={Journal of cellular physiology},
  volume={226 10},
During tooth development, inner enamel epithelial (IEE) cells differentiate into enamel-secreting ameloblasts, a polarized and elongated cellular population. The molecular underpinnings of this morphogenesis and cytodifferentiation, however, are not well understood. Here, we show that Rho-associated coiled-coil-containing protein kinase (ROCK) regulates ameloblast differentiation and enamel formation. In mouse incisor organ cultures, inhibition of ROCK, hindered IEE cell elongation and… CONTINUE READING
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