Functional role of P-glycoprotein in the human blood-placental barrier.

  title={Functional role of P-glycoprotein in the human blood-placental barrier.},
  author={Melissa M{\"o}ls{\"a} and Tuija Maarit Heikkinen and Jukka Hakkola and Kristo Eerik Hakala and Ola Wallerman and Mia Wadelius and Claes Wadelius and Kari Laine},
  journal={Clinical pharmacology and therapeutics},
  volume={78 2},
OBJECTIVE In vitro and animal experiments suggest that P-glycoprotein forms a functional barrier between maternal and fetal blood circulation in the placenta, thus protecting the fetus from exposure to xenobiotics during pregnancy. In this study we aimed to characterize the role of P-glycoprotein in the blood-placental barrier by use of dually perfused human placenta. METHODS Twenty-eight human placentas were obtained after delivery, and both the maternal side and the fetal side were perfused… CONTINUE READING

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