Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport.

@article{Varma2005FunctionalRO,
  title={Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport.},
  author={Manthena V S Varma and K. R. K. Sateesh and Ramesh V. Panchagnula},
  journal={Molecular pharmaceutics},
  year={2005},
  volume={2 1},
  pages={12-21}
}
The aim of the present study is to evaluate the quantitative contribution of passive permeability to P-glycoprotein-mediated (P-gp-mediated) efflux and the functional activity of P-gp in determining intestinal absorption of drugs, and demonstrate the relationship between efflux parameters and intestinal permeability. MDRI-MDCKII cell monolayer permeability, human intestinal absorption (HIA), and solubility data were systematically collected from the literature. Drugs were classified as a total… CONTINUE READING

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The aim of the present study is to evaluate the quantitative contribution of passive permeability to P - glycoprotein - mediated ( P - gp - mediated ) efflux and the functional activity of P - gp in determining intestinal absorption of drugs , and demonstrate the relationship between efflux parameters and intestinal permeability .
The aim of the present study is to evaluate the quantitative contribution of passive permeability to P - glycoprotein - mediated ( P - gp - mediated ) efflux and the functional activity of P - gp in determining intestinal absorption of drugs , and demonstrate the relationship between efflux parameters and intestinal permeability .
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