Functional role of CLC-2 chloride inward rectifier channels in cardiac sinoatrial nodal pacemaker cells.

@article{Huang2009FunctionalRO,
  title={Functional role of CLC-2 chloride inward rectifier channels in cardiac sinoatrial nodal pacemaker cells.},
  author={Zheng Maggie Huang and Chaithra Prasad and Fiona C Britton and Linda L Ye and William J. Hatton and Dayue Darrel Duan},
  journal={Journal of molecular and cellular cardiology},
  year={2009},
  volume={47 1},
  pages={121-32}
}
A novel Cl(-) inward rectifier channel (Cl,ir) encoded by ClC-2, a member of the ClC voltage-gated Cl(-) channel gene superfamily, has been recently discovered in cardiac myocytes of several species. However, the physiological role of Cl,ir channels in the heart remains unknown. In this study we tested the hypothesis that Cl,ir channels may play an important role in cardiac pacemaker activity. In isolated guinea-pig sinoatrial node (SAN) cells, Cl,ir current was activated by hyperpolarization… CONTINUE READING

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