Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.

@article{Thomas1993FunctionalRF,
  title={Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.},
  author={Everton A Thomas and Salah A Baker and Frederick J. Ehlert},
  journal={Molecular pharmacology},
  year={1993},
  volume={44 1},
  pages={
          102-10
        }
}
A functional role for the M2 muscarinic receptor in smooth muscle contraction was investigated in isolated guinea pig ileum. Contractile responses to the muscarinic agonist oxotremorine-M (oxo-M) were measured in isolated ilea that had been pretreated with histamine (0.32 microM) and isoproterenol (0.64 microM) to achieve conditions of elevated cAMP. The resulting concentration-effect curve was biphasic, consisting of high (0-50 nM) and low (> 50 nM) potency components. The reversible M2… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Muscarinic agonists and antagonists: effects on gastrointestinal function.

  • Handbook of experimental pharmacology
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder.

  • The Journal of pharmacology and experimental therapeutics
  • 2004
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.

  • The Journal of pharmacology and experimental therapeutics
  • 1999
VIEW 8 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED