Functional role for cannabinoids in respiratory stability during sleep.

@article{Carley2002FunctionalRF,
  title={Functional role for cannabinoids in respiratory stability during sleep.},
  author={David W. Carley and Sasa Paviovic and Marina Janelidze and Miodrag Radulovacki},
  journal={Sleep},
  year={2002},
  volume={25 4},
  pages={
          391-8
        }
}
STUDY OBJECTIVES Serotonin, acting in the peripheral nervous system, can exacerbate sleep-related apnea, and systemically administered serotonin antagonists reduce sleep-disordered respiration in rats and bulldogs. Because cannabinoid receptor agonists are known to inhibit the excitatory effects of serotonin on nodose ganglion cells, we examined the effects of endogenous (oleamide) and exogenous (delta9-tetrahydrocannabinol; delta9THC) cannabimimetic agents on sleep-related apnea. DESIGN… Expand
Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats
TLDR
Dronabinol's effects on apneas were dependent on CB1 receptor activation, while dronabinols effects on REM sleep were CB receptor-independent, according to a natural model of central sleep apnea. Expand
Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat
TLDR
It is shown that dronabinol injected locally into the nodose ganglia suppresses 5-HT-induced reflex apnea, and increases phasic, but not tonic, activation of the genioglossus, which supports the view that dRONabinol stabilizes respiratory pattern and augments upper airway muscles by acting at the nodoses ganglia. Expand
Title : Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat
Obstructive sleep apnea represents a significant public health concern. Afferent vagal activation is implicated in increased apnea susceptibility by reducing upper airway muscle tone via activationExpand
Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea
TLDR
Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5–10 mg daily and significantly reduces AHI in the short-term and should be confirmed in a larger study in order to identify sub-populations with OSA that may benefit from cannabimimetic pharmacologic therapy. Expand
Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study.
TLDR
Anandamide increased adenosine levels in the basal forebrain and also increased sleep in conditions where sleep may be severely attenuated, and this findings identify a potential therapeutic use of endocannabinoids to induce sleep in terms of dosage and mechanism. Expand
Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats
TLDR
The data show that ICV injection of dronabinol did not decrease 5-HT-induced apneas, and did not increase genioglossus activity, and this in contrast to published results of dRONabinol’s effect on apnea via the vagus nerve. Expand
Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals.
TLDR
In this chapter, the studies detailing the effects of cannabinoids on sleep in laboratory animals are reviewed and some evidence suggests that some sleep effects may be elicited via non-cannabinoid receptor-dependent mechanisms. Expand
DMSO potentiates the suppressive effect of dronabinol, a cannabinoid, on sleep apnea and REM sleep
TLDR
Dronabinol in 25% DMSO partially potentiated dronabinl’s effects, suggesting a concomitant biological effect of D MSO on breathing during sleep. Expand
Pharmacology of vagal afferent influences on disordered breathing during sleep
TLDR
Emerging work suggesting the importance of vagal afferent feedback systems in sleep-related respiratory pattern disturbances and pointing toward a rich but complex array of neurochemical and neuromodulatory processes that may be involved are summarized. Expand
Cannabinoid Type 1 and Type 2 Receptor Antagonists Prevent Attenuation of Serotonin-Induced Reflex Apneas by Dronabinol in Sprague-Dawley Rats
TLDR
Dronabinol injections into nodose ganglia of the CB1, CB2, and combined CB1/CB2 groups did not attenuate 5-HT-induced reflex apnea duration, and CB1 and CB2 antagonists had no effect on dronabinl’s ability to increase phasic EMGgg. Expand
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