Functional role for c-myc in mitogenic response to platelet-derived growth factor

@article{Armelin1984FunctionalRF,
  title={Functional role for c-myc in mitogenic response to platelet-derived growth factor},
  author={Hugo Aguirre Armelin and M. C. S. Armelin and Kathleen Kelly and Timothy Stewart and Philip Leder and Brent H Cochran and Charles Dean Stiles},
  journal={Nature},
  year={1984},
  volume={310},
  pages={655-660}
}
In BALB/c-3T3 cells, expression of the c-myc gene is stimulated by platelet-derived growth factor (PDGF). Using mouse mammary tumour virus promoter: c-myc recombinant plasmids, 3T3 sublines were constructed in which hydrocortisone was the primary determinant of myc mRNA content. The c-myc gene product is an intracellular mediator of the growth response to PDGF though probably not the only one. Both the human and the mouse c-myc genes stimulate clonal growth of 3T3 cells in PDGF-free medium… CONTINUE READING

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