Functional responses of the pulmonary endothelium to thoracic irradiation in rats: differential modification by D-penicillamine.

@article{Ward1987FunctionalRO,
  title={Functional responses of the pulmonary endothelium to thoracic irradiation in rats: differential modification by D-penicillamine.},
  author={William F. Ward and Agostino Molteni and Chung hsin Ts'ao and Norman H. Solliday},
  journal={International journal of radiation oncology, biology, physics},
  year={1987},
  volume={13 10},
  pages={
          1505-13
        }
}
Male rats were sacrificed 2 or 6 months after a range of single doses of gamma rays (0-30 Gy) to the right hemithorax. Half of each dose group consumed control feed continuously after irradiation, and half consumed feed containing the collagen antagonist D-penicillamine (10 mg/rat/day). Four markers of pulmonary endothelial function were monitored: angiotensin converting enzyme (ACE) activity, plasminogen activator (PLA) activity, and prostacyclin (PGI2) and thromboxane (TXA2) production… Expand
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References

SHOWING 1-10 OF 40 REFERENCES
Pulmonary endothelial dysfunction induced by unilateral as compared to bilateral thoracic irradiation in rats.
TLDR
Data demonstrate that pulmonary endothelial dysfunction induced by hemithorax irradiation represents a direct response of the endothelium to radiation injury and is not secondary to other phenomena such as shunting of function to the shielded lung. Expand
Radiation injury in rat lung. IV. Modification by D-penicillamine.
TLDR
The antifibrotic agent D-penicillamine delays the onset of radiation-induced enzyme dysfunction in the pulmonary endothelium and is most effective in ameliorating endothelial damage during the first 2 months after irradiation, preceding the development of interstitial fibrosis. Expand
Prostacyclin and Thromboxane Production by Irradiated Rat Lung
The production of prostacyclin (PGI2) and thromboxane (TXA2) by irradiated rat lung and the concentration of these prostanoids in the bronchoalveolar lavage (BAL) fluid were measured in ratsExpand
Radiation injury in rat lung. I. Prostacyclin (PGI2) production, arterial perfusion, and ultrastructure.
Pulmonary prostacyclin (PGI2) production, arterial perfusion, and ultrastructure were correlated in rats sacrificed from 1 day to 6 months after a single exposure of 25 Gy of gamma rays to the rightExpand
The relationship between endothelial dysfunction and collagen accumulation in irradiated rat lung.
TLDR
In rat lung, arterial perfusion, endothelial dysfunction and interstitial fibrosis, the dose-effect curves for these three responses of the lung in situ change less than 5% per Gy over the dose range of 10-30 Gy, a smaller variation than would be predicted from endothelial cell survival data based on clonogenic assays in vitro or in vivo. Expand
Plasminogen activator activity in lung and alveolar macrophages of rats exposed to graded single doses of gamma rays to the right hemithorax.
TLDR
Data quantitate the dose response and time course of radiation-induced fibrinolytic defects in rat lung and suggest that information obtained from a minimally invasive procedure such as bronchoalveolar lavage may serve as an index of the degree of pulmonary fibrin clot lysis dysfunction after irradiation. Expand
Monocrotaline-lnduced Pulmonary Endothelial Dysfunction in Rats
TLDR
Monocrotaline-induced pulmonary injury is accompanied, and in some cases preceded, by structural and functional abnormalities in the pulmonary endothelium, as visualized by 99mTc lung scans. Expand
The ultrastructure of radiation injury in rat lung: modification by D-penicillamine.
TLDR
Penicillamine treatment produces a generalized inhibition of pathologic events such as collagen accumulation and arterial wall thickening, and acceleration of restorative processes such as revascularization andmore » collagen degradation. Expand
Collagen accumulation in irradiated rat lung: modification by D-penicillamine.
The collagen antagonist D-penicillamine (10 mg/day, p.o.) significantly ameliorated radiation-induced hydroxyproline (HP) accumulation in the lungs of rats killed 3, 6, 9, or 12 months after a singleExpand
Late functional and biochemical changes in mouse lung after irradiation: differential effects of WR-2721.
TLDR
The data suggest that changes in breathing rate and deaths later than 9 months after whole lung irradiation may not be due to collagen accumulation in the lung, and protection of late lung damage measured from either lethality or breathing rate is not related to the prevention of lung fibrosis. Expand
...
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3
4
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