Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone.

@article{Huebner2008FunctionalRO,
  title={Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone.},
  author={Kyla D Huebner and Davinder S Jassal and Orna Halevy and Mark Pines and Judy E Anderson},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 4},
  pages={H1550-61}
}
The effect of halofuginone (Halo) on established fibrosis in older mdx dystrophic muscle was investigated. Mice (8 to 9 mo) treated with Halo (or saline in controls) for 5, 10, or 12 wk were assessed weekly for grip strength and voluntary running. Echocardiography was performed at 0, 5, and 10 wk. Respiratory function and exercise-induced muscle damage were tested. Heart, quadriceps, diaphragm, and tibialis anterior muscles were collected to study fibrosis, collagen I and III expression… CONTINUE READING
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