Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis.

@article{Dufourcq2002FunctionalRF,
  title={Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis.},
  author={Pascale Dufourcq and Martin Victor and Fr{\'e}d{\'e}rique A Gay and Dominica Calvo and Jonathan Hodgkin and Yang Shi},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 9},
  pages={3024-34}
}
Histone acetylation and deacetylation have been implicated in the regulation of gene expression. Molecular studies have shown that histone deacetylases (HDACs) function as transcriptional repressors. However, very little is known about their roles during development in multicellular organisms. We previously demonstrated that inhibition of maternal and zygotic expression of histone deacetylase 1 (HDA-1) causes embryonic lethality in Caenorhabditis elegans. Here, we report the identification of… CONTINUE READING

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