Functional replication of the tendon tissue microenvironment by a bioimprinted substrate and the support of tenocytic differentiation of mesenchymal stem cells.

@article{Tong2012FunctionalRO,
  title={Functional replication of the tendon tissue microenvironment by a bioimprinted substrate and the support of tenocytic differentiation of mesenchymal stem cells.},
  author={Wing Yin Tong and Wei Shen and Connie W F Yeung and Ying Zhao and Shuk Han Cheng and Paul K. Chu and Danny S K Chan and Godfrey Chi-fung Chan and Kenneth Man-Chee Cheung and Kelvin Wai Kwok Yeung and Yun Wah Lam},
  journal={Biomaterials},
  year={2012},
  volume={33 31},
  pages={7686-98}
}
Although many studies have demonstrated that cell phenotype is affected by the surface properties of biomaterials, these materials often fail to mimic the complexity of the native tissue microenvironment (TME). In this study, we have developed a new experimental model that allows the characterisation and functional reconstruction of natural TME. We discovered that mesenchymal stem cells (MSC) cultured on cryostat sections of bovine Achilles tendon adopted an elongated and aligned morphology… CONTINUE READING
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