Functional replacement of a retroviral late domain by ubiquitin fusion.

  title={Functional replacement of a retroviral late domain by ubiquitin fusion.},
  author={Anjali Joshi and Utpal M Munshi and Sherimay D. Ablan and Kunio Nagashima and Eric O. Freed},
  volume={9 11},
Retroviral Gag polyprotein precursors are both necessary and sufficient for the assembly and release of virus-like particles (VLPs) from infected cells. It is well established that small Gag-encoded motifs, known as late domains, promote particle release by interacting with components of the cellular endosomal sorting and ubiquitination machinery. The Gag proteins of a number of different retroviruses are ubiquitinated; however, the role of Gag ubiquitination in particle egress remains… CONTINUE READING
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