Functional repair of human donor lungs by IL-10 gene therapy.

@article{Cypel2009FunctionalRO,
  title={Functional repair of human donor lungs by IL-10 gene therapy.},
  author={Marcelo Cypel and Mingyao Liu and Matt Rubacha and Jonathan C Yeung and Shin Hirayama and Masaki Anraku and Masaaki Sato and Jeffrey A. Medin and Beverly L. Davidson and Marc E de Perrot and Thomas K Waddell and Arthur S Slutsky and Shaf H Keshavjee},
  journal={Science translational medicine},
  year={2009},
  volume={1 4},
  pages={4ra9}
}
More than 80% of potential donor lungs are injured during brain death of the donor and from complications experienced in the intensive care unit, and therefore cannot be used for transplantation. These lungs show inflammation and disruption of the alveolar-capillary barrier, leading to poor gas exchange. Although the number of patients in need of lung transplantation is increasing, the number of donors is static. We investigated the potential to use gene therapy with an adenoviral vector… CONTINUE READING

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