Functional reorganization of the rat motor cortex following motor skill learning.

@article{Kleim1998FunctionalRO,
  title={Functional reorganization of the rat motor cortex following motor skill learning.},
  author={Jeffrey A. Kleim and Scott Barbay and Randolph J. Nudo},
  journal={Journal of neurophysiology},
  year={1998},
  volume={80 6},
  pages={
          3321-5
        }
}
Functional reorganization of the rat motor cortex following motor skill learning. J. Neurophysiol. 80: 3321-3325, 1998. Adult rats were allocated to either a skilled or unskilled reaching condition (SRC and URC, respectively). SRC animals were trained for 10 days on a skilled reaching task while URC animals were trained on a simple bar pressing task. After training, microelectrode stimulation was used to derive high resolution maps of the forelimb and hindlimb representations within the motor… 
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References

SHOWING 1-10 OF 36 REFERENCES
Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys
TLDR
The finding that cocontracting muscles in the behavior come to be represented together in the cortex argues that, as in sensory cortices, temporal correlations drive emergent changes in distributed motor cortex representations.
Adaptive Plasticity in Primate Motor Cortex as a Consequence of Behavioral Experience and Neuronal Injury
TLDR
The studies suggest that the neurophysiological circuitry underlying muscle and movement maps within primary motor cortex is continually remodeled throughout an individual's life.
Functional subdivisions of the rat somatic sensorimotor cortex
Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning
TLDR
The data suggest that Fos may be involved in the biochemical processes underlying skill acquisition and that motor learning, as opposed to motor activity, leads to increases in synapse number in the motor cortex.
Selective Synaptic Plasticity within the Cerebellar Cortex Following Complex Motor Skill Learning
TLDR
The learning-dependent increase in synapse number observed within the cerebellar cortex is accomplished primarily through the addition of parallel fiber synapses, mainly to Purkinje cell synapses.
Tactile experience determines the organization of movement representations in rat motor cortex.
TLDR
These findings indicate that a relatively innocuous procedure that restricts sensory and motor functions results in pronounced, and reversible, changes in the functional organization of the motor cortex of rats that had their mystacial vibrissae clipped continually for various periods during their development.
A second forelimb motor area exists in rat frontal cortex
Effects of unilateral and bilateral training in a reaching task on dendritic branching of neurons in the rat motor-sensory forelimb cortex.
A chronic unit study of the sensory properties of neurons in the forelimb areas of rat sensorimotor cortex
Deficits in contralateral and ipsilateral forepaw motor control following unilateral motor cortical ablations in rats
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