Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.

Abstract

The herpes simplex virus (HSV) type 1 immediate-early regulatory protein ICP4 is required for induced expression of HSV early and late genes, yet the mechanism by which this occurs is not known. We examined the promoter and flanking sequences of the HSV early gene that encodes thymidine kinase for the ability to interact specifically with ICP4 in gel… (More)

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@article{Imbalzano1990FunctionalRO, title={Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.}, author={Anthony N. Imbalzano and Alexandra Shepard and Neal A DeLuca}, journal={Journal of virology}, year={1990}, volume={64 6}, pages={2620-31} }