Functional relationships between Rad18 and WRNIP1 in vertebrate cells.

Abstract

The WRNIP1 protein interacts with WRN, the product of the causative gene for Werner syndrome. Mutation of the Saccharomyces cerevisiae gene MGS1, the yeast counterpart of WRNIP1, confers synthetic lethality with mutation of RAD18. To examine the functional relationship between WRNIP1 and Rad18 in higher eukaryotic cells, we generated WRNIP1-/-/-/RAD18… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.