Functional regeneration of respiratory pathways after spinal cord injury

@inproceedings{Alilain2011FunctionalRO,
  title={Functional regeneration of respiratory pathways after spinal cord injury},
  author={Warren Joseph Alilain and Kevin Paul Horn and Hongmei Hu and Thomas E. Dick and Jerry Silver},
  booktitle={Nature},
  year={2011}
}
Spinal cord injuries often occur at the cervical level above the phrenic motor pools, which innervate the diaphragm. The effects of impaired breathing are a leading cause of death from spinal cord injuries, underscoring the importance of developing strategies to restore respiratory activity. Here we show that, after cervical spinal cord injury, the expression of chondroitin sulphate proteoglycans (CSPGs) associated with the perineuronal net (PNN) is upregulated around the phrenic motor neurons… CONTINUE READING
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