Functional redundancy within roX1, a noncoding RNA involved in dosage compensation in Drosophila melanogaster.

Abstract

Drosophila melanogaster males dosage compensate by twofold upregulation of the expression of genes on their single X chromosome. This process requires at least five proteins and two noncoding RNAs, roX1 and roX2, which paint the male X chromosome. We used a deletion analysis to search for functional RNA domains within roX1, assaying RNA stability, targeting… (More)

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