Functional redundancy of extracellular matrix protein 1 in epidermal differentiation.

  title={Functional redundancy of extracellular matrix protein 1 in epidermal differentiation.},
  author={Sandy Sercu and Yves Poumay and Françoise Herphelin and Joeri Liekens and Lisette Beek and An Zwijsen and Vesarat Wessagowit and Danny Huylebroeck and J A McGrath and Joseph H Merregaert},
  journal={The British journal of dermatology},
  volume={157 4},
BACKGROUND Extracellular matrix protein 1 (ECM1) is a secreted protein expressed in skin. Its dermatological relevance has been highlighted by the discovery of loss-of-function mutations in ECM1 in patients with lipoid proteinosis (LiP). OBJECTIVES To determine the role of ECM1 in epidermal differentiation by examining gene and protein expression of epidermal differentiation markers in individuals with LiP and histological assessment of transgenic mouse skin that overexpresses Ecm1a in basal… CONTINUE READING