Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis.

  title={Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis.},
  author={Mirta S Grifman and N Galyam and Shlomo Seidman and Hermona Soreq},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 23},
Accumulated evidence attributes noncatalytic morphogenic activitie(s) to acetylcholinesterase (AChE). Despite sequence homologies, functional overlaps between AChE and catalytically inactive AChE-like cell surface adhesion proteins have been demonstrated only for the Drosophila protein neurotactin. Furthermore, no mechanism had been proposed to enable signal transduction by AChE, an extracellular enzyme. Here, we report impaired neurite outgrowth and loss of neurexin Ialpha mRNA under antisense… CONTINUE READING
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Grifman et al

  • M. Grifman, E. Lev-Lehman, +9 authors pp. 141–167. 13940 Neurobiology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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