Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.

@article{Liu2011FunctionalRB,
  title={Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.},
  author={Hongbing Liu and Chao-Hui Chen and Ram{\'o}n A. Espinoza-Lewis and Zhen Jiao and Ivana Sheu and Xuefeng Hu and Minkui Lin and Yanding Zhang and Yiping Chen},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 19},
  pages={17029-38}
}
The homeodomain transcription factor Shox2 plays a crucial regulatory role in the development of sinoatrial node (SAN) by repressing the expression of Nkx2.5, as demonstrated by failed differentiation of SAN in Shox2 null mice. The SHOX (short stature homeobox) gene family consists of two closely related members, SHOX and SHOX2 in humans, but a SHOX ortholog does not exist in the mouse genome. These two genes exhibit overlapping and distinct expression patterns in many developing organs but… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…