Functional recycling of C2 domains throughout evolution: a comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches.

@article{Jimnez2003FunctionalRO,
  title={Functional recycling of C2 domains throughout evolution: a comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches.},
  author={Jos{\'e} Luis Dom{\'i}nguez Jim{\'e}nez and Graham R. Smith and Bruno Contreras-Moreira and John G. Sgouros and Fr{\'e}d{\'e}ric A Meunier and Paul A. Bates and Giampietro Schiavo},
  journal={Journal of molecular biology},
  year={2003},
  volume={333 3},
  pages={621-39}
}
The C2 domain is one of the most frequent and widely distributed calcium-binding motifs. Its structure comprises an eight-stranded beta-sandwich with two structural types as if the result of a circular permutation. Combining sequence, structural and modelling information, we have explored, at different levels of granularity, the functional characteristics… CONTINUE READING