Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.

@article{Claypool2002FunctionalRO,
  title={Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.},
  author={Steven M Claypool and Bonny L. Dickinson and Masaru Yoshida and Wayne I Lencer and Richard S Blumberg},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 31},
  pages={28038-50}
}
The major histocompatibility complex class I-related neonatal Fc receptor, FcRn, assembles as a heterodimer consisting of a heavy chain and beta(2)-microglobulin (beta(2)m), which is essential for FcRn function. We observed that, in Madin-Darby canine kidney (MDCK) cells, the function of human FcRn in mediating the bidirectional transport of IgG was significantly increased upon co-expression of the human isoform of beta(2)m. In MDCK cells, the presence of human beta(2)m endowed upon human FcRn… CONTINUE READING

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