Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance.

@article{Boulin2011FunctionalRO,
  title={Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance.},
  author={Thomas Boulin and Aymeric Fauvin and Claude L. Charvet and Jacques Cortet and Jacques Cabaret and J-L Bessereau and Cedric Neveu},
  journal={British journal of pharmacology},
  year={2011},
  volume={164 5},
  pages={1421-32}
}
BACKGROUND AND PURPOSE The cholinergic agonist levamisole is widely used to treat parasitic nematode infestations. This anthelmintic drug paralyses worms by activating a class of levamisole-sensitive acetylcholine receptors (L-AChRs) expressed in nematode muscle cells. However, levamisole efficacy has been compromised by the emergence of drug-resistant parasites, especially in gastrointestinal nematodes such as Haemonchus contortus. We report here the first functional reconstitution and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms

International journal for parasitology. Drugs and drug resistance • 2015
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Resistance to levamisole resolved at the single-channel level.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1999
View 6 Excerpts
Highly Influenced

Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008
View 4 Excerpts
Highly Influenced

Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2006
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…