Functional proton transfer pathways in the heme-copper oxidase superfamily.

  title={Functional proton transfer pathways in the heme-copper oxidase superfamily.},
  author={Hyun Ju Lee and Joachim Reimann and Yafei Huang and Pia Adelroth},
  journal={Biochimica et biophysica acta},
  volume={1817 4},
Heme-copper oxidases (HCuOs) terminate the respiratory chain in mitochondria and most bacteria. They are transmembrane proteins that catalyse the reduction of oxygen and use the liberated free energy to maintain a proton-motive force across the membrane. The HCuO superfamily has been divided into the oxygen-reducing A-, B- and C-type oxidases as well as the bacterial NO reductases (NOR), catalysing the reduction of NO in the denitrification process. Proton transfer to the catalytic site in the… CONTINUE READING

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