Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.

  title={Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.},
  author={Jochen Schwenk and Nadine Harmel and Gerd Zolles and Wolfgang Bildl and {\'A}kos Kulik and Bernd Heimrich and Osamu Chisaka and P{\'e}ter J{\'o}n{\'a}s and U. Schulte and Bernd Fakler and Nikolaj Kl{\"o}cker},
  volume={323 5919},
Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are coassembled with two members of the cornichon family of transmembrane proteins, rather than with the TARPs. Coassembly with cornichon homologs 2 and 3 affects AMPARs in two ways: Cornichons increase surface expression of AMPARs… CONTINUE READING
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